Personally, it won't affect my site at all because right now I don't have any ads on my site. (I just pay for my hosting out of my own pocket and don't try to monetize it.)
But if I were in a situation where I had to rely on external funding of some sort, And I had opted to use adsense... I'd probably do 2 things.
1- I'd post up a note asking people not to use adblock because the existence of our site depends upon revenue generated by adsense. And if ads are blocked then we don't get any money at all.
2- I'd create a VIP, Donator or Subscriber type group that has ad-free for a perk. (I'd try to come up with others though too just so it wasn't the only advantage.)
This way people who didn't want to see ads, but still wanted to support the site could give money directly to us.
If things got really bad and people refused to stop using adblock then I'd probably resort to more drastic measures... like blocking content for people who use adblock. It might not be perfect, but it wouldn't have to be. Sometimes people just don't realize how problematic blocking adsense is for sites. And by just a simple script to check for adblock (and block content if found) it'd be enough to get people to help support a site instead.
Don't get me wrong though, I like adsense and there are cases where I support it's use. (Auto play video ads are obnoxious and need to stop. Especially on pages where there's already video content you want to watch.) But it should be used in moderation and held off for sites you trust/like and want to support.